Ontology highlight
ABSTRACT:
SUBMITTER: Erchegyi J
PROVIDER: S-EPMC5959268 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Erchegyi Judit J Wang Lixin L Gulyas Jozsef J Samant Manoj M Perrin Marilyn H MH Lewis Kathy K Miller Charleen C Vaughan Joan J Donaldson Cynthia C Fischer Wolfgang W Low William W Yakabi Seiichi S Karasawa Hiroshi H Taché Yvette Y Rivier Catherine C Rivier Jean J
Journal of medicinal chemistry 20160203 3
CRF mediates numerous stress-related endocrine, autonomic, metabolic, and behavioral responses. We present the synthesis and chemical and biological properties of astressin B analogues {cyclo(30-33)[D-Phe(12),Nle(21,38),C(α)MeLeu(27,40),Glu(30),Lys(33)]-acetyl-h/r-CRF(9-41)}. Out of 37 novel peptides, 17 (2, 4, 6-8, 10, 11, 16, 17, 27, 29, 30, 32-36) and 16 (3, 5, 9, 12-15, 18, 19, 22-26, 28, 31) had k(i) to CRF receptors in the high picomolar and low nanomole ranges, respectively. Peptides 1, 2 ...[more]