Ontology highlight
ABSTRACT:
SUBMITTER: Smink AM
PROVIDER: S-EPMC5960477 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Smink Alexandra M AM de Vos Paul P
Current diabetes reports 20180519 7
<h4>Purposes of review</h4>Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve transplantation outcomes. This review discusses the current therapeutic strategies to modulate ECM components to improve islet engraftment.<h4>Recent findings</h4>Approaches ...[more]