Clinical efficacy of teriflunomide over a fixed 2-year duration in the TOWER study.
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ABSTRACT:
SUBMITTER: Freedman MS
PROVIDER: S-EPMC5960864 | biostudies-literature | 2018 Apr-Jun
REPOSITORIES: biostudies-literature
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Clinical efficacy of teriflunomide over a fixed 2-year duration in the TOWER study.
Freedman Mark S MS Morawski Julia J Thangavelu Karthinathan K
Multiple sclerosis journal - experimental, translational and clinical 20180401 2
Patients enrolled in the phase 3 TOWER study (NCT00751881) of teriflunomide had variable treatment durations (48-173 weeks). This has led to challenges when interpreting results in the context of other phase 3 trials of disease-modifying therapies for multiple sclerosis, which typically have a fixed 2-year duration. This communication reports clinical outcomes in TOWER over a fixed 2-year period. Reductions in annualised relapse rates and 12-week confirmed disability worsening associated with te ...[more]
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