Ontology highlight
ABSTRACT:
SUBMITTER: Laks DR
PROVIDER: S-EPMC5961175 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Laks Dan R DR Oses-Prieto Juan A JA Alvarado Alvaro G AG Nakashima Jonathan J Chand Shreya S Azzam Daniel B DB Gholkar Ankur A AA Sperry Jantzen J Ludwig Kirsten K Condro Michael C MC Nazarian Serli S Cardenas Anjelica A Shih Michelle Y S MYS Damoiseaux Robert R France Bryan B Orozco Nicholas N Visnyei Koppany K Crisman Thomas J TJ Gao Fuying F Torres Jorge Z JZ Coppola Giovanni G Burlingame Alma L AL Kornblum Harley I HI
Neuro-oncology 20180501 6
<h4>Background</h4>Clinical trials of therapies directed against nodes of the signaling axis of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin (mTOR) in glioblastoma (GBM) have had disappointing results. Resistance to mTOR inhibitors limits their efficacy.<h4>Methods</h4>To determine mechanisms of resistance to chronic mTOR inhibition, we performed tandem screens on patient-derived GBM cultures.<h4>Results</h4>An unbiased phosphoproteomic screen quantified phosphorylation change ...[more]