Ontology highlight
ABSTRACT:
SUBMITTER: Ah-Pine F
PROVIDER: S-EPMC7569239 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Ah-Pine Franck F Casas Déborah D Menei Philippe P Boisselier Blandine B Garcion Emmanuel E Rousseau Audrey A
Translational oncology 20201015 1
Glioblastoma (GBM) is the most frequent and most aggressive form of glioma. It is characterized by marked genomic instability, which suggests that chromothripsis (CT) might be involved in GBM initiation. Recently, CT has emerged as an alternative mechanism of cancer development, involving massive chromosome rearrangements in a one-step catastrophic event. The aim of the study was to detect CT in GBM and identify novel gene fusions in CT regions. One hundred and seventy IDH-wild-type GBM were scr ...[more]