Ontology highlight
ABSTRACT:
SUBMITTER: Lim CS
PROVIDER: S-EPMC5961209 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nucleic acids research 20180501 9
Introns in mRNA leaders are common in complex eukaryotes, but often overlooked. These introns are spliced out before translation, leaving exon-exon junctions in the mRNA leaders (leader EEJs). Our multi-omic approach shows that the number of leader EEJs inversely correlates with the main protein translation, as does the number of upstream open reading frames (uORFs). Across the five species studied, the lowest levels of translation were observed for mRNAs with both leader EEJs and uORFs (29%). T ...[more]