Ontology highlight
ABSTRACT:
SUBMITTER: Taylor MD
PROVIDER: S-EPMC5961491 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Taylor Matthew D MD Burn Thomas N TN Wherry E John EJ Behrens Edward M EM
ImmunoHorizons 20180201 2
Familial hemophagocytic lymphohistiocytosis 2 (FHL2) is a cytokine storm syndrome characterized by immune hyperactivation with viral infection due to a CD8 T cell cytotoxic killing defect secondary to a perforin deficiency. As most studies of FHL2 mice have used pathogen naïve animals, the effects of immune memory on FHL2 are understudied. We utilized an immunization model of the perforin-deficient mouse to study the effects of immune memory on FHL2. Prior CD8 T cell specific antigen exposure le ...[more]