Ontology highlight
ABSTRACT:
SUBMITTER: Coleman JA
PROVIDER: S-EPMC5962350 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Coleman Jonathan A JA Gouaux Eric E
Nature structural & molecular biology 20180129 2
Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by increasing the local concentrations of neurotransmitters at synapses and in extracellular spaces via blockade of the serotonin transporter. Here we report X-ray structures of engineered thermostable variants of the human serotonin transporter bound to the antidepressants sertraline, fluvoxamine, and paroxetine. The drugs prevent serotonin binding by occupying the central substrate-binding site and stabi ...[more]