Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC3644373 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Wang Chong C Jiang Yi Y Ma Jinming J Wu Huixian H Wacker Daniel D Katritch Vsevolod V Han Gye Won GW Liu Wei W Huang Xi-Ping XP Vardy Eyal E McCorvy John D JD Gao Xiang X Zhou X Edward XE Melcher Karsten K Zhang Chenghai C Bai Fang F Yang Huaiyu H Yang Linlin L Jiang Hualiang H Roth Bryan L BL Cherezov Vadim V Stevens Raymond C RC Xu H Eric HE
Science (New York, N.Y.) 20130321 6132
Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT receptor family. We report the crystal structures of the human 5-HT1B G protein-coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine. The structures reveal similar binding modes for these ligands, which occupy the orthosteric pocket and an extended binding pocket close to the extracellular loops. The orthosteric pocket is formed by residues conserved i ...[more]