Ontology highlight
ABSTRACT:
SUBMITTER: Strominger I
PROVIDER: S-EPMC5962702 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Strominger Itai I Elyahu Yehezqel Y Berner Omer O Reckhow Jensen J Mittal Kritika K Nemirovsky Anna A Monsonego Alon A
Frontiers in immunology 20180516
The choroid plexus (CP) compartment in the ventricles of the brain comprises fenestrated vasculature and, therefore, it is permeable to blood-borne mediators of inflammation. Here, we explored whether T-cell activation in the CP plays a role in regulating central nervous system (CNS) inflammation. We show that CD4 T cells injected into the lateral ventricles adhere to the CP, transmigrate across its epithelium, and undergo antigen-specific activation and proliferation. This process is enhanced f ...[more]