Dataset Information

Identification of micro-RNA expression profile related to recurrence in women with ESMO low-risk endometrial cancer.

ABSTRACT:

Background

Actual European pathological classification of early-stage endometrial cancer (EC) may show insufficient accuracy to precisely stratify recurrence risk, leading to potential over or under treatment. Micro-RNAs are post-transcriptional regulators involved in carcinogenic mechanisms, with some micro-RNA patterns of expression associated with EC characteristics and prognosis. We previously demonstrated that downregulation of micro-RNA-184 was associated with lymph node involvement in low-risk EC (LREC). The aim of this study was to evaluate whether micro-RNA signature in tumor tissues from LREC women can be correlated with the occurrence of recurrences.

Methods

MicroRNA expression was assessed by chip analysis and qRT-PCR in 7 formalin-fixed paraffin-embedded (FFPE) LREC primary tumors from women whose follow up showed recurrences (R+) and in 14 FFPE LREC primary tumors from women whose follow up did not show any recurrence (R-), matched for grade and age. Various statistical analyses, including enrichment analysis and a minimum p-value approach, were performed.

Results

The expression levels of micro-RNAs-184, -497-5p, and -196b-3p were significantly lower in R+ compared to R- women. Women with a micro-RNA-184 fold change??0.083 (n?=?1; 8%), p?=?0.016. Women with a micro-RNA-196 fold change??0.56 (n?=?2; 13%), p?=?0.001.

Conclusions

These findings confirm the great interest of micro-RNA-184 as a prognostic tool to improve the management of LREC women.

SUBMITTER: de Foucher T

PROVIDER: S-EPMC5963057 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Identification of micro-RNA expression profile related to recurrence in women with ESMO low-risk endometrial cancer.

de Foucher Tiphaine T Sbeih Maria M Uzan Jenifer J Bendifallah Sofiane S Lefevre Marine M Chabbert-Buffet Nathalie N Aractingi Selim S Uzan Catherine C Abd Alsalam Issam I Mitri Rana R Fontaine Romain H RH Daraï Emile E Haddad Bassam B Méhats Céline C Ballester Marcos M Canlorbe Geoffroy G Touboul Cyril C

Journal of translational medicine 20180521 1

<h4>Background</h4>Actual European pathological classification of early-stage endometrial cancer (EC) may show insufficient accuracy to precisely stratify recurrence risk, leading to potential over or under treatment. Micro-RNAs are post-transcriptional regulators involved in carcinogenic mechanisms, with some micro-RNA patterns of expression associated with EC characteristics and prognosis. We previously demonstrated that downregulation of micro-RNA-184 was associated with lymph node involvemen ...[more]

PMID: 29783999

Similar Datasets

Project description:ObjectiveTo examine the association between ovarian conservation and oncologic outcome in surgically-treated young women with early-stage, low-grade endometrial cancer.MethodsThis multicenter retrospective study examined women aged <50 with stage I grade 1-2 endometrioid endometrial cancer who underwent primary surgery with hysterectomy from 2000 to 2014 (US cohort n = 1196, and Japan cohort n = 495). Recurrence patterns, survival, and the presence of a metachronous secondary malignancy were assessed based on ovarian conservation versus oophorectomy.ResultsDuring the study period, the ovarian conservation rate significantly increased in the US cohort from 5.4% to 16.4% (P = 0.020) whereas the rate was unchanged in the Japan cohort (6.3-8.7%, P = 0.787). In the US cohort, ovarian conservation was not associated with disease-free survival (hazard ratio [HR] 0.829, 95% confidence interval [CI] 0.188-3.663, P = 0.805), overall survival (HR not estimated, P = 0.981), or metachronous secondary malignancy (HR 1.787, 95% CI 0.603-5.295, P = 0.295). In the Japan cohort, ovarian conservation was associated with decreased disease-free survival (HR 5.214, 95% CI 1.557-17.464, P = 0.007) and an increased risk of a metachronous secondary malignancy, particularly ovarian cancer (HR 7.119, 95% CI 1.349-37.554, P = 0.021), but was not associated with overall survival (HR not estimated, P = 0.987). Ovarian recurrence or metachronous secondary ovarian cancer occurred after a median time of 5.9 years, and all cases were salvaged.ConclusionOur study suggests that adoption of ovarian conservation in young women with early-stage low-grade endometrial cancer varies by population. Ovarian conservation for young women with early-stage, low-grade endometrial cancer may be potentially associated with increased risks of ovarian recurrence or metachronous secondary ovarian cancer in certain populations; nevertheless, ovarian conservation did not negatively impact overall survival.

Dataset Information

Identification of micro-RNA expression profile related to recurrence in women with ESMO low-risk endometrial cancer.

Background

Methods

Results

Conclusions

Publications

Identification of micro-RNA expression profile related to recurrence in women with ESMO low-risk endometrial cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets