Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
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ABSTRACT:
SUBMITTER: Regan MC
PROVIDER: S-EPMC5963293 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Regan Michael C MC Grant Timothy T McDaniel Miranda J MJ Karakas Erkan E Zhang Jing J Traynelis Stephen F SF Grigorieff Nikolaus N Furukawa Hiro H
Neuron 20180412 3
Alternative gene splicing gives rise to N-methyl-D-aspartate (NMDA) receptor ion channels with defined functional properties and unique contributions to calcium signaling in a given chemical environment in the mammalian brain. Splice variants possessing the exon-5-encoded motif at the amino-terminal domain (ATD) of the GluN1 subunit are known to display robustly altered deactivation rates and pH sensitivity, but the underlying mechanism for this functional modification is largely unknown. Here, ...[more]
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