Ontology highlight
ABSTRACT:
SUBMITTER: Mamonkin M
PROVIDER: S-EPMC5963729 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Mamonkin Maksim M Mukherjee Malini M Srinivasan Madhuwanti M Sharma Sandhya S Gomes-Silva Diogo D Mo Feiyan F Krenciute Giedre G Orange Jordan S JS Brenner Malcolm K MK
Cancer immunology research 20171027 1
T cells expressing second-generation chimeric antigen receptors (CARs) specific for CD5, a T-cell surface marker present on normal and malignant T cells, can selectively kill tumor cells. We aimed to improve this killing by substituting the CD28 costimulatory endodomain (28.z) with 4-1BB (BB.z), as 28.z CD5 CAR T cells rapidly differentiated into short-lived effector cells. In contrast, 4-1BB costimulation is known to promote development of the central memory subpopulation. Here, we found BB.z C ...[more]