Ontology highlight
ABSTRACT:
SUBMITTER: Cooper ML
PROVIDER: S-EPMC6102094 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cooper Matthew L ML Choi Jaebok J Staser Karl K Ritchey Julie K JK Devenport Jessica M JM Eckardt Kayla K Rettig Michael P MP Wang Bing B Eissenberg Linda G LG Ghobadi Armin A Gehrs Leah N LN Prior Julie L JL Achilefu Samuel S Miller Christopher A CA Fronick Catrina C CC O'Neal Julie J Gao Feng F Weinstock David M DM Gutierrez Alejandro A Fulton Robert S RS DiPersio John F JF
Leukemia 20180220 9
T cell malignancies represent a group of hematologic cancers with high rates of relapse and mortality in patients for whom no effective targeted therapies exist. The shared expression of target antigens between chimeric antigen receptor (CAR) T cells and malignant T cells has limited the development of CAR-T because of unintended CAR-T fratricide and an inability to harvest sufficient autologous T cells. Here, we describe a fratricide-resistant "off-the-shelf" CAR-T (or UCART7) that targets CD7+ ...[more]