Ontology highlight
ABSTRACT:
SUBMITTER: Heise C
PROVIDER: S-EPMC5963824 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cerebral cortex (New York, N.Y. : 1991) 20170301 3
Alterations in the balance of inhibitory and excitatory synaptic transmission have been implicated in the pathogenesis of neurological disorders such as epilepsy. Eukaryotic elongation factor 2 kinase (eEF2K) is a highly regulated, ubiquitous kinase involved in the control of protein translation. Here, we show that eEF2K activity negatively regulates GABAergic synaptic transmission. Indeed, loss of eEF2K increases GABAergic synaptic transmission by upregulating the presynaptic protein Synapsin 2 ...[more]