Ontology highlight
ABSTRACT:
SUBMITTER: Fernandes KA
PROVIDER: S-EPMC5964014 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Fernandes Kimberly A KA Mitchell Katherine L KL Patel Amit A Marola Olivia J OJ Shrager Peter P Zack Donald J DJ Libby Richard T RT Welsbie Derek S DS
Experimental eye research 20180308
Optic neuropathies such as glaucoma are characterized by the degeneration of retinal ganglion cells (RGCs) and the irreversible loss of vision. In these diseases, focal axon injury triggers a propagating axon degeneration and, eventually, cell death. Previous work by us and others identified dual leucine zipper kinase (DLK) and JUN N-terminal kinase (JNK) as key mediators of somal cell death signaling in RGCs following axonal injury. Moreover, others have shown that activation of the DLK/JNK pat ...[more]