Ontology highlight
ABSTRACT:
SUBMITTER: Blount BA
PROVIDER: S-EPMC5964169 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nature communications 20180522 1
Synthetic biology tools, such as modular parts and combinatorial DNA assembly, are routinely used to optimise the productivity of heterologous metabolic pathways for biosynthesis or substrate utilisation, yet it is well established that host strain background is just as important for determining productivity. Here we report that in vivo combinatorial genomic rearrangement of Saccharomyces cerevisiae yeast with a synthetic chromosome V can rapidly generate new, improved host strains with genetic ...[more]