Ontology highlight
ABSTRACT:
SUBMITTER: Park SY
PROVIDER: S-EPMC4793076 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Park Seung-Yoon SY Yun Youngeun Y Lim Jung-Suk JS Kim Mi-Jin MJ Kim Sang-Yeob SY Kim Jung-Eun JE Kim In-San IS
Nature communications 20160314
Myoblast fusion is essential for the formation of skeletal muscle myofibres. Studies have shown that phosphatidylserine is necessary for myoblast fusion, but the underlying mechanism is not known. Here we show that the phosphatidylserine receptor stabilin-2 acts as a membrane protein for myoblast fusion during myogenic differentiation and muscle regeneration. Stabilin-2 expression is induced during myogenic differentiation, and is regulated by calcineurin/NFAT signalling in myoblasts. Forced exp ...[more]