Ontology highlight
ABSTRACT:
SUBMITTER: Sosulski ML
PROVIDER: S-EPMC5964739 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Sosulski Meredith L ML Gongora Rafael R Feghali-Bostwick Carol C Lasky Joseph A JA Sanchez Cecilia G CG
The journals of gerontology. Series A, Biological sciences and medical sciences 20170501 5
Oxidative stress leads to alveolar epithelial cell injury and fibroblast-myofibroblast differentiation (FMD), key events in the pathobiology of pulmonary fibrosis (PF). Sirtuin 3 (SIRT3) is a mitochondrial protein deacetylase regulator of antioxidant response and mitochondrial homeostasis. Here, we demonstrate reduced SIRT3 expression in the lungs of old mice compared to young mice, as well as in two murine models of PF. The analysis of the pattern of SIRT3 expression in the lungs of patients wi ...[more]