Ontology highlight
ABSTRACT:
SUBMITTER: Wiley CD
PROVIDER: S-EPMC6975274 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wiley Christopher D CD Brumwell Alexis N AN Davis Sonnet S SS Jackson Julia R JR Valdovinos Alexis A Calhoun Cheresa C Alimirah Fatouma F Castellanos Carlos A CA Ruan Richard R Wei Ying Y Chapman Harold A HA Ramanathan Arvind A Campisi Judith J Jourdan Le Saux Claude C
JCI insight 20191219 24
Accumulation of senescent cells is associated with the progression of pulmonary fibrosis, but mechanisms accounting for this linkage are not well understood. To explore this issue, we investigated whether a class of biologically active profibrotic lipids, the leukotrienes (LT), is part of the senescence-associated secretory phenotype. The analysis of conditioned medium (CM), lipid extracts, and gene expression of LT biosynthesis enzymes revealed that senescent cells secreted LT, regardless of th ...[more]