Ontology highlight
ABSTRACT:
SUBMITTER: Ulbrich S
PROVIDER: S-EPMC5965872 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ulbrich Sarah S Janning Petra P Seidel Ralf R Matschke Jakob J Gonsberg Anika A Jung Sebastian S Glatzel Markus M Engelhard Martin M Winklhofer Konstanze F KF Tatzelt Jörg J
PloS one 20180523 5
The cellular prion protein (PrPC) is implicated in neuroprotective signaling and neurotoxic pathways in both prion diseases and Alzheimer's disease (AD). Specifically, the intrinsically disordered N-terminal domain (N-PrP) has been shown to interact with neurotoxic ligands, such as Aβ and Scrapie prion protein (PrPSc), and to be crucial for the neuroprotective activity of PrPC. To gain further insight into cellular pathways tied to PrP, we analyzed the brain interactome of N-PrP. As a novel appr ...[more]