Ontology highlight
ABSTRACT:
SUBMITTER: Matlik K
PROVIDER: S-EPMC5966223 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Mätlik Kert K Anttila Jenni E JE Kuan-Yin Tseng T Smolander Olli-Pekka OP Pakarinen Emmi E Lehtonen Leevi L Abo-Ramadan Usama U Lindholm Päivi P Zheng Congjun C Harvey Brandon B Arumäe Urmas U Lindahl Maria M Airavaara Mikko M
Science advances 20180523 5
Stroke is the most common cause of adult disability in developed countries, largely because spontaneous recovery is often incomplete, and no pharmacological means to hasten the recovery exist. It was recently shown that mesencephalic astrocyte-derived neurotrophic factor (MANF) induces alternative or M2 activation of immune cells after retinal damage in both fruit fly and mouse and mediates retinal repair. Therefore, we set out to study whether poststroke MANF administration would enhance brain ...[more]