Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC5966422 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Zhang Jianbin J Wang Jigang J Wong Yin Kwan YK Sun Xin X Chen Yun Y Wang Liming L Yang Liu L Lu Liqin L Shen Han-Ming HM Huang Dongsheng D
Cell death & disease 20180523 6
Docetaxel is an effective and commonly used chemotherapeutic drug for cancer. Autophagy has been reported to be involved in the anticancer mechanism of docetaxel. However, the effect of docetaxel on lysosomal function remains elusive. In the present study, we first found that docetaxel treatment enhances autophagic flux in different cancer cells. Moreover, docetaxel treatment activates lysosomal function and promotes its fusion with autophagosome. Second, doctaxel treatment activates TFEB (trans ...[more]