Ontology highlight
ABSTRACT:
SUBMITTER: Dudka D
PROVIDER: S-EPMC5966435 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Dudka Damian D Noatynska Anna A Smith Chris A CA Liaudet Nicolas N McAinsh Andrew D AD Meraldi Patrick P
Nature communications 20180523 1
Kinetochores are multi-protein complexes that power chromosome movements by tracking microtubules plus-ends in the mitotic spindle. Human kinetochores bind up to 20 microtubules, even though single microtubules can generate sufficient force to move chromosomes. Here, we show that high microtubule occupancy at kinetochores ensures robust chromosome segregation by providing a strong mechanical force that favours segregation of merotelic attachments during anaphase. Using low doses of the microtubu ...[more]