Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects.

ABSTRACT: BACKGROUND:Gut microbiota-derived short-chain fatty acids (SCFAs) have been associated with beneficial metabolic effects. However, the direct effect of oral butyrate on metabolic parameters in humans has never been studied. In this first in men pilot study, we thus treated both lean and metabolic syndrome male subjects with oral sodium butyrate and investigated the effect on metabolism. METHODS:Healthy lean males (n?=?9) and metabolic syndrome males (n?=?10) were treated with oral 4?g of sodium butyrate daily for 4 weeks. Before and after treatment, insulin sensitivity was determined by a two-step hyperinsulinemic euglycemic clamp using [6,6-2H2]-glucose. Brown adipose tissue (BAT) uptake of glucose was visualized using 18F-FDG PET-CT. Fecal SCFA and bile acid concentrations as well as microbiota composition were determined before and after treatment. RESULTS:Oral butyrate had no effect on plasma and fecal butyrate levels after treatment, but did alter other SCFAs in both plasma and feces. Moreover, only in healthy lean subjects a significant improvement was observed in both peripheral (median Rd: from 71 to 82?µmol/kg?min, p?

SUBMITTER: Bouter K 

PROVIDER: S-EPMC5968024 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature