Dataset Information

Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women.

ABSTRACT:

Objective

To evaluate the effects of a commonly used combined hormonal oral contraceptive (OC) on carbohydrate metabolism in obese as compared with lean women.

Design

6-month prospective study.

Setting

Clinical research center at an academic medical center.

Patient(s)

Premenopausal nondiabetic women with body mass index <25 kg/m(2) (n = 15) or >30 kg/m(2) (n = 14).

Intervention(s)

Ethinyl estradiol (35 ?g) and norgestimate (0.18/0.215/0.25 mg) for 6 cycles.

Main outcome measure(s)

Insulin sensitivity by frequent sampling intravenous glucose tolerance test; other indices of insulin sensitivity (homeostatic model assessment of insulin sensitivity index [ISI HOMA], the Matsuda index); fasting lipid panel.

Result(s)

Insulin sensitivity changed from 6.62 ± 3.69 min(-1)/mIU/L (baseline) to 8.23 ± 3.30 min(-1)/mIU/L (6 months) in lean women, and from 4.36 ± 2.32 to 3.82 ± 2.32 min(-1)/mIU/L in obese women. Divergent effects on insulin sensitivity were also observed with ISI HOMA and the Matsuda index. Low-density lipoprotein increased by approximately 20 mg/dL in both the lean and obese groups.

Conclusion(s)

Lean and obese women exhibit differential changes in insulin sensitivity when given 6 months of a commonly used oral contraceptive. The mechanisms of these differences and whether these divergent effects persist in the long term require further investigation.

SUBMITTER: Cheang KI

PROVIDER: S-EPMC3143285 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women.

Cheang Kai I KI Essah Paulina A PA Sharma Susmeeta S Wickham Edmond P EP Nestler John E JE

Fertility and sterility 20110615 2

<h4>Objective</h4>To evaluate the effects of a commonly used combined hormonal oral contraceptive (OC) on carbohydrate metabolism in obese as compared with lean women.<h4>Design</h4>6-month prospective study.<h4>Setting</h4>Clinical research center at an academic medical center.<h4>Patient(s)</h4>Premenopausal nondiabetic women with body mass index <25 kg/m(2) (n = 15) or >30 kg/m(2) (n = 14).<h4>Intervention(s)</h4>Ethinyl estradiol (35 μg) and norgestimate (0.18/0.215/0.25 mg) for 6 cycles.<h4 ...[more]

PMID: 21676394

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Dataset Information

Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women.

Objective

Design

Setting

Patient(s)

Intervention(s)

Main outcome measure(s)

Result(s)

Conclusion(s)

Publications

Divergent effects of a combined hormonal oral contraceptive on insulin sensitivity in lean versus obese women.

Similar Datasets

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