Ontology highlight
ABSTRACT:
SUBMITTER: Yayla HG
PROVIDER: S-EPMC5968518 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Chemical science 20151207 3
Elbasvir is a potent NS5A antagonist for the treatment of chronic hepatitis C. A seemingly trivial indoline oxidation en route to the target compound was complicated by epimerization of a stereogenic hemiaminal center under most standard oxidation conditions. To address this issue, a novel visible light photoredox process for indoline oxidation was developed involving an iridium photosensitizer and environmentally-benign perester oxidant. The reaction was discovered through a high-throughput exp ...[more]