Dataset Information

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.

ABSTRACT: Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990-1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.

SUBMITTER: Silventoinen K

PROVIDER: S-EPMC5969906 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.

Silventoinen Karri K Jelenkovic Aline A Latvala Antti A Sund Reijo R Yokoyama Yoshie Y Ullemar Vilhelmina V Almqvist Catarina C Derom Catherine A CA Vlietinck Robert F RF Loos Ruth J F RJF Kandler Christian C Honda Chika C Inui Fujio F Iwatani Yoshinori Y Watanabe Mikio M Rebato Esther E Stazi Maria A MA Fagnani Corrado C Brescianini Sonia S Hur Yoon-Mi YM Jeong Hoe-Uk HU Cutler Tessa L TL Hopper John L JL Busjahn Andreas A Saudino Kimberly J KJ Ji Fuling F Ning Feng F Pang Zengchang Z Rose Richard J RJ Koskenvuo Markku M Heikkilä Kauko K Cozen Wendy W Hwang Amie E AE Mack Thomas M TM Siribaddana Sisira H SH Hotopf Matthew M Sumathipala Athula A Rijsdijk Fruhling F Sung Joohon J Kim Jina J Lee Jooyeon J Lee Sooji S Nelson Tracy L TL Whitfield Keith E KE Tan Qihua Q Zhang Dongfeng D Llewellyn Clare H CH Fisher Abigail A Burt S Alexandra SA Klump Kelly L KL Knafo-Noam Ariel A Mankuta David D Abramson Lior L Medland Sarah E SE Martin Nicholas G NG Montgomery Grant W GW Magnusson Patrik K E PKE Pedersen Nancy L NL Dahl Aslan Anna K AK Corley Robin P RP Huibregtse Brooke M BM Öncel Sevgi Y SY Aliev Fazil F Krueger Robert F RF McGue Matt M Pahlen Shandell S Willemsen Gonneke G Bartels Meike M van Beijsterveldt Catharina E M CEM Silberg Judy L JL Eaves Lindon J LJ Maes Hermine H HH Harris Jennifer R JR Brandt Ingunn I Nilsen Thomas S TS Rasmussen Finn F Tynelius Per P Baker Laura A LA Tuvblad Catherine C Ordoñana Juan R JR Sánchez-Romera Juan F JF Colodro-Conde Lucia L Gatz Margaret M Butler David A DA Lichtenstein Paul P Goldberg Jack H JH Harden K Paige KP Tucker-Drob Elliot M EM Duncan Glen E GE Buchwald Dedra D Tarnoki Adam D AD Tarnoki David L DL Franz Carol E CE Kremen William S WS Lyons Michael J MJ Maia José A JA Freitas Duarte L DL Turkheimer Eric E Sørensen Thorkild I A TIA Boomsma Dorret I DI Kaprio Jaakko J

Twin research and human genetics : the official journal of the International Society for Twin Studies 20171001 5

Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for ...[more]

PMID: 28975875

Similar Datasets

Project description:Rationale: Pooling data from multiple cohorts and extending the time frame across childhood should minimize study-specific effects, enabling better characterization of childhood wheezing. Objectives: To analyze wheezing patterns from early childhood to adolescence using combined data from five birth cohorts. Methods: We used latent class analysis to derive wheeze phenotypes among 7,719 participants from five birth cohorts with complete report of wheeze at five time periods. We tested the associations of derived phenotypes with late asthma outcomes and lung function, and investigated the uncertainty in phenotype assignment. Results: We identified five phenotypes: never/infrequent wheeze (52.1%), early onset preschool remitting (23.9%), early onset midchildhood remitting (9%), persistent (7.9%), and late-onset wheeze (7.1%). Compared with the never/infrequent wheeze, all phenotypes had higher odds of asthma and lower forced expiratory volume in 1 second and forced expiratory volume in 1 second/forced vital capacity in adolescence. The association with asthma was strongest for persistent wheeze (adjusted odds ratio, 56.54; 95% confidence interval, 43.75-73.06). We observed considerable within-class heterogeneity at the individual level, with 913 (12%) children having low membership probability (<0.60) of any phenotype. Class membership certainty was highest in persistent and never/infrequent, and lowest in late-onset wheeze (with 51% of participants having membership probabilities <0.80). Individual wheezing patterns were particularly heterogeneous in late-onset wheeze, whereas many children assigned to early onset preschool remitting class reported wheezing at later time points. Conclusions: All wheeze phenotypes had significantly diminished lung function in school-age children, suggesting that the notion that early life episodic wheeze has a benign prognosis may not be true for a proportion of transient wheezers. We observed considerable within-phenotype heterogeneity in individual wheezing patterns.

Dataset Information

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.

Publications

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets