Dataset Information

Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project.

ABSTRACT: BACKGROUND:There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM:To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS:This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69?years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. RESULTS:Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25?cm and 0.18-0.90?cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. CONCLUSION:Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.

SUBMITTER: Jelenkovic A

PROVIDER: S-EPMC6532975 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project.

Jelenkovic Aline A Yokoyama Yoshie Y Sund Reijo R Hur Yoon-Mi YM Harris Jennifer R JR Brandt Ingunn I Nilsen Thomas Sevenius TS Ooki Syuichi S Ullemar Vilhelmina V Almqvist Catarina C Magnusson Patrik K E PKE Saudino Kimberly J KJ Stazi Maria A MA Fagnani Corrado C Brescianini Sonia S Nelson Tracy L TL Whitfield Keith E KE Knafo-Noam Ariel A Mankuta David D Abramson Lior L Cutler Tessa L TL Hopper John L JL Llewellyn Clare H CH Fisher Abigail A Corley Robin P RP Huibregtse Brooke M BM Derom Catherine A CA Vlietinck Robert F RF Bjerregaard-Andersen Morten M Beck-Nielsen Henning H Sodemann Morten M Krueger Robert F RF McGue Matt M Pahlen Shandell S Alexandra Burt S S Klump Kelly L KL Dubois Lise L Boivin Michel M Brendgen Mara M Dionne Ginette G Vitaro Frank F Willemsen Gonneke G Bartels Meike M van Beijsterveld Catharina E M CEM Craig Jeffrey M JM Saffery Richard R Rasmussen Finn F Tynelius Per P Heikkilä Kauko K Pietiläinen Kirsi H KH Bayasgalan Gombojav G Narandalai Danshiitsoodol D Haworth Claire M A CMA Plomin Robert R Ji Fuling F Ning Feng F Pang Zengchang Z Rebato Esther E Tarnoki Adam D AD Tarnoki David L DL Kim Jina J Lee Jooyeon J Lee Sooji S Sung Joohon J Loos Ruth J F RJF Boomsma Dorret I DI Sørensen Thorkild I A TIA Kaprio Jaakko J Silventoinen Karri K

Early human development 20180412

<h4>Background</h4>There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment.<h4>Aim</h4>To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.<h4>Methods</h4>This study is based ...[more]

PMID: 29656171

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Project description:Rationale: Pooling data from multiple cohorts and extending the time frame across childhood should minimize study-specific effects, enabling better characterization of childhood wheezing. Objectives: To analyze wheezing patterns from early childhood to adolescence using combined data from five birth cohorts. Methods: We used latent class analysis to derive wheeze phenotypes among 7,719 participants from five birth cohorts with complete report of wheeze at five time periods. We tested the associations of derived phenotypes with late asthma outcomes and lung function, and investigated the uncertainty in phenotype assignment. Results: We identified five phenotypes: never/infrequent wheeze (52.1%), early onset preschool remitting (23.9%), early onset midchildhood remitting (9%), persistent (7.9%), and late-onset wheeze (7.1%). Compared with the never/infrequent wheeze, all phenotypes had higher odds of asthma and lower forced expiratory volume in 1 second and forced expiratory volume in 1 second/forced vital capacity in adolescence. The association with asthma was strongest for persistent wheeze (adjusted odds ratio, 56.54; 95% confidence interval, 43.75-73.06). We observed considerable within-class heterogeneity at the individual level, with 913 (12%) children having low membership probability (<0.60) of any phenotype. Class membership certainty was highest in persistent and never/infrequent, and lowest in late-onset wheeze (with 51% of participants having membership probabilities <0.80). Individual wheezing patterns were particularly heterogeneous in late-onset wheeze, whereas many children assigned to early onset preschool remitting class reported wheezing at later time points. Conclusions: All wheeze phenotypes had significantly diminished lung function in school-age children, suggesting that the notion that early life episodic wheeze has a benign prognosis may not be true for a proportion of transient wheezers. We observed considerable within-phenotype heterogeneity in individual wheezing patterns.

Dataset Information

Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project.

Publications

Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project.

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