Short- and Long-Term Changes in Health-Related Quality of Life with Weight Loss: Results from a Randomized Controlled Trial.

ABSTRACT: OBJECTIVE:The objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight-specific health-related quality of life in a 66-week trial. METHODS:Adults with obesity (N?=?137, 86.1% female, 68.6% black, mean age?=?46.1 years) who had lost???5% of initial weight in a 14-week intensive lifestyle intervention/low-calorie diet (LCD) program were randomly assigned to lorcaserin or placebo for an additional 52-week WLM program. The Impact of Weight on Quality of Life-Lite (IWQOL-Lite) scale (including five subscales), Patient Health Questionnaire-9 (depression), and Perceived Stress Scale were administered at the start of the 14-week LCD program, randomization, and week 52 of the randomized controlled trial (i.e., 66 weeks total). RESULTS:Significant improvements in all outcomes, except weight-related public distress, were found following the 14-week LCD program (P values

SUBMITTER: Pearl RL 

PROVIDER: S-EPMC5970047 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature