The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
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ABSTRACT:
SUBMITTER: Diplas BH
PROVIDER: S-EPMC5970234 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
Diplas Bill H BH He Xujun X Brosnan-Cashman Jacqueline A JA Liu Heng H Chen Lee H LH Wang Zhaohui Z Moure Casey J CJ Killela Patrick J PJ Loriaux Daniel B DB Lipp Eric S ES Greer Paula K PK Yang Rui R Rizzo Anthony J AJ Rodriguez Fausto J FJ Friedman Allan H AH Friedman Henry S HS Wang Sizhen S He Yiping Y McLendon Roger E RE Bigner Darell D DD Jiao Yuchen Y Waitkus Matthew S MS Meeker Alan K AK Yan Hai H
Nature communications 20180525 1
The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These molecular subgroups utilize distinct genetic mechanisms of telomere maintenance, either TERTp mutation leading to telomerase activation or ATRX-mutation leading to an alternative lengthening of telomeres phenotype (ALT). However, about 20% of glioblastomas lack alterations in TERTp and IDH. These tumors, designated TERTp<sup>WT< ...[more]
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