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Immunotherapy in Breast Cancer: the New Frontier.

ABSTRACT: Purpose of review:This review summarizes current immunotherapies in breast cancer, with an emphasis on immune checkpoint inhibitors and vaccines. Recent findings:Combination immunotherapy with checkpoint inhibitors and cytotoxic therapies have shown promising results. Active clinical trials are ongoing in both early stage and metastatic settings for triple negative, HER2+, and hormone-positive breast cancer patients. Summary:Ongoing challenges remain in defining biomarkers that predict response to immunotherapy, determining the optimal combination immunotherapies, and enhancing the immunogenicity of breast cancer subtypes.

SUBMITTER: Hu ZI 

PROVIDER: S-EPMC5970253 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Immunotherapy in Breast Cancer: the New Frontier.

Hu Zishuo I ZI   McArthur Heather L HL  

Current breast cancer reports 20180416 2

<h4>Purpose of review</h4>This review summarizes current immunotherapies in breast cancer, with an emphasis on immune checkpoint inhibitors and vaccines.<h4>Recent findings</h4>Combination immunotherapy with checkpoint inhibitors and cytotoxic therapies have shown promising results. Active clinical trials are ongoing in both early stage and metastatic settings for triple negative, HER2+, and hormone-positive breast cancer patients.<h4>Summary</h4>Ongoing challenges remain in defining biomarkers  ...[more]

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