Ontology highlight
ABSTRACT:
SUBMITTER: Luscher A
PROVIDER: S-EPMC5971595 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Luscher Alexandre A Moynié Lucile L Auguste Pamela Saint PS Bumann Dirk D Mazza Lena L Pletzer Daniel D Naismith James H JH Köhler Thilo T
Antimicrobial agents and chemotherapy 20180525 6
The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria. In this Trojan horse approach, the transport of drug conjugates is redirected via TonB-dependent receptors (TBDR), which are involved in the uptake of essential nutrients, including iron. Previous reports have demonstrated the involvement of the TBDRs PiuA and PirA from <i>Pseudomonas aeruginosa</i> and their orthologues in <i>Acinetobact ...[more]