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Phenotypical adaptation of Pseudomonas aeruginosa in the presence of siderophore-antibiotic conjugates during epithelial cell infection

ABSTRACT: This study aims at investigating the ability of Pseudomonas aeruginosa to detect the presence of siderophore-antibiotic conjugates in an epithelial cell infection assay. We show that the presence of siderophore-antibiotic conjugates induces the transcription and expression of their corresponding transporters, indicating the bacteria are able to sense the chelators in their environment and adapt their phenotype accordingly.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human) Pseudomonas Aeruginosa Pao1

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Paola Cantero

LAB HEAD: Laurence Sabatier

PROVIDER: PXD020378 | Pride | 2021-02-18

REPOSITORIES: Pride

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			Action	DRS
	QE20036LC.dat	Other
	QE20036LC.mgf	Mgf
	QE20036LC.mzDB	Other
	QE20036LC.raw	Raw
	QE20039LC.dat	Other

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Phenotypic adaptation of Pseudomonas aeruginosa by hacking siderophores produced by other microorganisms

Project description:This study aims at investigating the ability of Pseudomonas aeruginosa to detect the presence of exosiderophores in an epithelial cell infection assay. We show that the presence of exosiderophores induces the transcription and expression of their corresponding transporters, and that bacteria sense the presence of the chelators in their environment and adapt their phenotype to access iron via the exosiderophore present

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