Ontology highlight
ABSTRACT:
SUBMITTER: O'Sullivan BJ
PROVIDER: S-EPMC5972300 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
O'Sullivan Brendan J BJ Yekollu Suman S Ruscher Roland R Mehdi Ahmed M AM Maradana Muralidhara Rao MR Chidgey Ann P AP Thomas Ranjeny R
Frontiers in immunology 20180522
Polymorphisms impacting thymic function may decrease peripheral tolerance and hasten autoimmune disease. The NF-κB transcription factor subunit, RelB, is essential for the development and differentiation of medullary thymic epithelial cells (mTECs): RelB-deficient mice have reduced thymic cellularity and markedly fewer mTECs, lacking AIRE. The precise mechanism of this mTEC reduction in the absence of RelB is unclear. To address this, we studied mTECs and dendritic cells (DCs), which critically ...[more]