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[Research Progress in the Therapeutic Strategy Based on Targeting at ?Lung Cancer Stem Cell].

ABSTRACT: With high morbidity and mortality, lung cancer is a major threat to human health and one of the focuses of tumor researches. Lung cancer stem cells (LCSCs) are regarded as a subpopulation of cells within lung cancer tissues with the capacity of self-renewal and differentiation, and might be related to tumorigenesis and heterogeneity of lung cancer. Tumor recurrence, metastasis and drug resistance of lung cancers could be clarified by LCSC hypothesis. Thus it's therapeutically prospective to target at these cells. This review summarizes the biomarkers of LCSCs and their aberrant signal pathways, as well as the therapeutic strategies targeting at LCSCs.

SUBMITTER: Lai H

PROVIDER: S-EPMC5972359 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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[Research Progress in the Therapeutic Strategy Based on Targeting at  Lung Cancer Stem Cell].

Lai Hongjin H Lin Feng F Chen Nan N Wen Shu S Hu Xiao X Liu Lunxu L

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20180101 1

With high morbidity and mortality, lung cancer is a major threat to human health and one of the focuses of tumor researches. Lung cancer stem cells (LCSCs) are regarded as a subpopulation of cells within lung cancer tissues with the capacity of self-renewal and differentiation, and might be related to tumorigenesis and heterogeneity of lung cancer. Tumor recurrence, metastasis and drug resistance of lung cancers could be clarified by LCSC hypothesis. Thus it's therapeutically prospective to targ ...[more]

PMID: 29357974

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