Unknown

Dataset Information

0

[Research Progress of CDK4/6 Inhibitors in Non-small Cell Lung Cancer].


ABSTRACT: Lung cancer is the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) accounts for 80%-85% of lung cancer. Malignant tumors can proliferate indefinitely, and cell cycle regulation is abnormal which is one of the characteristics of malignant tumor. Cyclin D-dependent kinase (CDK) 4/6 inhibitor can prevent tumor cells from entering S phase through G? phase and inhibit tumor proliferation. The CDK4/6 inhibitor has achieved good effect in hormone receptor positive breast cancer, and CDK4/6 inhibitor combined with endocrine therapy has become a standard treatment for this kind of patients. Cell cycle regulation is usually abnormal in NSCLC, which incidence is about 22%-45%. CDK4/6 inhibitors have also carried out a series of research and achieved some results, which may become a new treatment in the future. This review focuses on the research progress of CDK4/6 inhibitors in NSCLC, including the mechanism and the approved drugs, clinical research progress in NSCLC, biomarkers for efficacy prediction and current limitations.

SUBMITTER: Qin Q 

PROVIDER: S-EPMC7118338 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

[Research Progress of CDK4/6 Inhibitors in Non-small Cell Lung Cancer].

Qin Qiong Q   Ren Yaoyao Y   Zhong Diansheng D  

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20200227 3


Lung cancer is the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) accounts for 80%-85% of lung cancer. Malignant tumors can proliferate indefinitely, and cell cycle regulation is abnormal which is one of the characteristics of malignant tumor. Cyclin D-dependent kinase (CDK) 4/6 inhibitor can prevent tumor cells from entering S phase through G₁ phase and inhibit tumor proliferation. The CDK4/6 inhibitor has achieved good effect in hormone receptor positive br  ...[more]

Similar Datasets

| S-EPMC5999922 | biostudies-literature
| S-EPMC9190697 | biostudies-literature
| S-EPMC5264037 | biostudies-literature
| S-EPMC10162406 | biostudies-literature
| S-EPMC8143967 | biostudies-literature
| S-EPMC6318572 | biostudies-literature
| S-EPMC4047835 | biostudies-literature
| S-EPMC10891408 | biostudies-literature
| S-EPMC9898162 | biostudies-literature
| S-EPMC5972355 | biostudies-literature