Ontology highlight
ABSTRACT:
SUBMITTER: Amcheslavsky A
PROVIDER: S-EPMC5972739 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Amcheslavsky Alla A Wang Shiuan S Fogarty Caitlin E CE Lindblad Jillian L JL Fan Yun Y Bergmann Andreas A
Developmental cell 20180501 4
Caspases are best characterized for their function in apoptosis. However, they also have non-apoptotic functions such as apoptosis-induced proliferation (AiP), where caspases release mitogens for compensatory proliferation independently of their apoptotic role. Here, we report that the unconventional myosin, Myo1D, which is known for its involvement in left/right development, is an important mediator of AiP in Drosophila. Mechanistically, Myo1D translocates the initiator caspase Dronc to the bas ...[more]