Ontology highlight
ABSTRACT:
SUBMITTER: Petrovsky R
PROVIDER: S-EPMC5973253 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Petrovsky Roman R Großhans Jörg J
Nucleus (Austin, Tex.) 20180101 1
The nuclear lamina is involved in numerous cellular functions, such as gene expression, nuclear organization, nuclear stability, and cell proliferation. The mechanism underlying the involvement of lamina is often not clear, especially in physiological or developmental contexts. Here we investigate the role and activity of farnesylated lamina proteins Lamin (Lam) and Kugelkern (Kuk) in proliferation control of intestinal stem cells (ISCs) in adult Drosophila flies. We found that ISCs mutant for L ...[more]