Ontology highlight
ABSTRACT:
SUBMITTER: Barton LJ
PROVIDER: S-EPMC6160405 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Barton Lacy J LJ Duan Tingting T Ke Wenfan W Luttinger Amy A Lovander Kaylee E KE Soshnev Alexey A AA Geyer Pamela K PK
Nature communications 20180927 1
LEM domain (LEM-D) proteins are conserved components of the nuclear lamina (NL) that contribute to stem cell maintenance through poorly understood mechanisms. The Drosophila emerin homolog Otefin (Ote) is required for maintenance of germline stem cells (GSCs) and gametogenesis. Here, we show that ote mutants carry germ cell-specific changes in nuclear architecture that are linked to GSC loss. Strikingly, we found that both GSC death and gametogenesis are rescued by inactivation of the DNA damage ...[more]