Dataset Information

[Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer ?and Its Clinical Significance].

ABSTRACT: The expression of long noncoding RNA HOX antisense RNA (HOTAIR) is abnormal in a variety of tumors. The aim of this study is to explore the serum levels and clinical significance of HOTAIR in patients with non-small cell lung cancer (NSCLC).The serum levels of HOTAIR were detected by real-time quantitative polymerase chain reaction (PCR) in 64 NSCLC patients and 64 normal controls. The relationships between the serum levels of HOTAIR and clinical pathological parameters were analyzed.Compared with normal controls, the serum levels of HOTAIR in patients with NSCLC increased significantly (P<0.01). The serum levels of HOTAIR were correlated with tumor size, tumor-node-metastasis (TNM) stage and lymph node metastasis (P<0.05), but not with age, gender, smoking, differentiation and histology (P>0.05).The serum levels of HOTAIR in patients with NSCLC are significantly higher, and HOTAIR may be involved in the pathogenesis of NSCLC.

SUBMITTER: Tan N

PROVIDER: S-EPMC5973358 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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[Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer  and Its Clinical Significance].

Tan Nan N Li Lihong L Bai Lu L Zhao Kun K

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20170601 6

<h4>Background</h4>The expression of long noncoding RNA HOX antisense RNA (HOTAIR) is abnormal in a variety of tumors. The aim of this study is to explore the serum levels and clinical significance of HOTAIR in patients with non-small cell lung cancer (NSCLC).<h4>Methods</h4>The serum levels of HOTAIR were detected by real-time quantitative polymerase chain reaction (PCR) in 64 NSCLC patients and 64 normal controls. The relationships between the serum levels of HOTAIR and clinical pathological p ...[more]

PMID: 28641698

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Project description:OBJECTIVE:Vascular-targeted therapy is gradually becoming more appealing for patients with lung cancer. It is unclear whether vascular endothelial growth factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1) can be biomarkers for clinical treatment. We aimed to investigate the expression levels of VEGFR2 and NRP-1 in human non-small cell lung cancer (NSCLC) and their clinical significance by observing patient prognosis. METHODS:VEGFR2 and NRP-1 were assessed by immunohistochemistry (IHC) in 40 patients with NSCLC and in 10 patients with benign lesions of lung; kinase insert domain receptor (KDR) and NRP-1 copy number gain (CNG) was assessed by fluorescence in situ hybridization (FISH). The distributions of overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method and compared between groups by log-rank test. RESULTS:Rates of positive immunostaining for VEGFR2 and NRP-1 were 58% and 55%, respectively. KDR and NRP-1 CNG (+) were detected in 32.5% and 30% of tumors, respectively. Levels of both VEGFR2 and NRP-1 in lung tumors were significantly different than in the control tissue (?(2)=11.22, P=0.001; ?(2)=9.82, P=0.001, respectively); similar results were obtained using CNGs (?(2)=4.39, P=0.036; ?(2)=3.95, P=0.046, respectively). Statistically significant correlations were observed with histological grade, clinical TNM stage and the lymph node status (P<0.05), but not age, gender or pathology type (P>0.05). VEGFR2 showed a strong correlation with NRP-1 (Rs=0.68, P=0.00); similar results were observed with KDR and NRP-1 CNG (Rs=0.32, P=0.04). Significant differences in OS and PFS were observed between the groups with higher VEGFR2 and NRP-1 and those with lower expression (P<0.05). CONCLUSIONS:According to these data, VEGFR2 and NRP-1 are highly expressed in NSCLC. We can conclude that they play a key role in NSCLC occurrence, development and metastasis and are associated with patient prognosis (P<0.05 for OS and PFS). This information will be beneficial for clinical anti-angiogenic treatment in NSCLC.

Dataset Information

[Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer ?and Its Clinical Significance].

Publications

[Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer  and Its Clinical Significance].

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Dataset Information

[Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer ?and Its Clinical Significance].

Publications

[Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer and Its Clinical Significance].

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

[Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer  and Its Clinical Significance].