Ontology highlight
ABSTRACT:
SUBMITTER: May CK
PROVIDER: S-EPMC5973619 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
May Christopher K CK Carroll Christopher W CW
PloS one 20180529 5
LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements. Most human cells contain two SUN proteins, Sun1 and Sun2, and several KASH-proteins suggesting that multiple functionally distinct LINC complexes co-exist in the nuclear envelope. We show here, however, that while Sun1 and Sun2 in HeLa cells are each able to bind KASH-domains, Sun1 is more efficientl ...[more]