Ontology highlight
ABSTRACT:
SUBMITTER: Hilmi M
PROVIDER: S-EPMC5974576 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Hilmi Marc M Bartholin Laurent L Neuzillet Cindy C
World journal of gastroenterology 20180501 20
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, mostly due to its resistance to treatment. Of these, checkpoint inhibitors (CPI) are inefficient when used as monotherapy, except in the case of a rare subset of tumors harboring microsatellite instability (< 2%). This inefficacy mainly resides in the low immunogenicity and non-inflamed phenotype of PDAC. The abundant stroma generates a hypoxic microenvironment and drives the recruitment of immunosuppressive cells through c ...[more]