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β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp)-H bonds using a palladium catalyst.

ABSTRACT: An efficient method of selective β-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp³)-H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp³)-C(sp²) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp³)-H functionalization.

SUBMITTER: Peng J

PROVIDER: S-EPMC5975923 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp)-H bonds using a palladium catalyst.

Peng Jing J Chen Chao C Xi Chanjuan C

Chemical science 20151111 2

An efficient method of selective β-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp3)-H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp3)-C(sp2) bonds on a number of complex molecules derived from natural products and thus serves as a ...[more]

PMID: 29910895

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