β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp)-H bonds using a palladium catalyst.

ABSTRACT: An efficient method of selective β-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp³)-H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp³)-C(sp²) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp³)-H functionalization.

SUBMITTER: Peng J 

PROVIDER: S-EPMC5975923 | biostudies-literature |

REPOSITORIES: biostudies-literature