Ontology highlight
ABSTRACT:
SUBMITTER: Shen K
PROVIDER: S-EPMC5975964 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Shen Kuang K Huang Rick K RK Brignole Edward J EJ Condon Kendall J KJ Valenstein Max L ML Chantranupong Lynne L Bomaliyamu Aimaiti A Choe Abigail A Hong Chuan C Yu Zhiheng Z Sabatini David M DM
Nature 20180328 7699
Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex-comprising DEPDC5, NPRL2 and NPRL3-regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvation. GATOR1 components have no sequence homology to other proteins, so the function of GATOR1 at the molecular level is currently unknown. Here we used cryo-electron microscopy to solve structures of GATOR ...[more]