Ontology highlight
ABSTRACT:
SUBMITTER: Chia KH
PROVIDER: S-EPMC5752196 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Chia Kim Hou KH Fukuda Tomoyuki T Sofyantoro Fajar F Matsuda Takato T Amai Takamitsu T Shiozaki Kazuhiro K
eLife 20171204
TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that promotes cellular macromolecular synthesis and suppresses autophagy. Amino-acid-induced activation of mammalian TORC1 is initiated by its recruitment to the RagA/B-RagC/D GTPase heterodimer, which is anchored to lysosomal membranes through the Ragulator complex. We have identified in the model organism <i>Schizosaccharomyces pombe</i> a Ragulator-like complex that tethers the Gtr1-Gtr2 Rag heterodimer to the membran ...[more]