Ontology highlight
ABSTRACT:
SUBMITTER: Sepulveda G
PROVIDER: S-EPMC5976437 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sepulveda Guadalupe G Antkowiak Mark M Brust-Mascher Ingrid I Mahe Karan K Ou Tingyoung T Castro Noemi M NM Christensen Lana N LN Cheung Lee L Jiang Xueer X Yoon Daniel D Huang Bo B Jao Li-En LE
eLife 20180430
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis. At mitosis onset, centrosomes maximize microtubule-organizing activity by rapidly expanding the pericentriolar material (PCM). This process is in part driven by the large PCM protein pericentrin (PCNT), as its level increases at the PCM and helps recruit additional PCM components. However, the mechanism underlying the timely centrosomal enrichment ...[more]