Ontology highlight
ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC5976438 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yang Chao C Tsaih Shirng-Wern SW Lemke Angela A Flister Michael J MJ Thakar Monica S MS Malarkannan Subramaniam S
eLife 20180529
Natural killer (NK) cells are innate lymphoid cells that are essential for innate and adaptive immunity. Mechanistic target of rapamycin (mTOR) is critical for NK cell development; however, the independent roles of mTORC1 or mTORC2 in regulating this process remain unknown. <i>Ncr1<sup>iCre</sup></i>-mediated deletion of <i>Rptor</i> or <i>Rictor</i> in mice results in altered homeostatic NK cellularity and impaired development at distinct stages. The transition from the CD27<sup>+</sup>CD11b<su ...[more]