Ontology highlight
ABSTRACT:
SUBMITTER: Banh C
PROVIDER: S-EPMC3512235 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Banh Cindy C Miah S M Shahjahan SM Kerr William G WG Brossay Laurent L
Blood 20121003 23
The SH2-containing inositol phosphatase-1 (SHIP-1) is a 5' inositol phosphatase known to negatively regulate the product of phosphoinositide-3 kinase (PI3K), phosphatidylinositol-3.4,5-trisphosphate. SHIP-1 can be recruited to a large number of inhibitory receptors expressed on natural killer (NK) cells. However, its role in NK cell development, maturation, and functions is not well defined. In this study, we found that the absence of SHIP-1 results in a loss of peripheral NK cells. However, usi ...[more]