Ontology highlight
ABSTRACT:
SUBMITTER: Mahajani NS
PROVIDER: S-EPMC5976556 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Mahajani Nivedita S NS Chisholm John D JD
Organic & biomolecular chemistry 20180501 21
1,1'-Diarylbutyl groups are a common pharmacophore found in many biologically active small molecules. To access these systems under mild conditions, the reaction of diarylmethyl trichloroacetimidates with allyltributylstannanes was explored. Simply heating allyltributylstannane with the trichloroacetimidate resulted in substitution of the imidate with an allyl group. Unlike other methods used to access these systems, no strong base, transition metal catalyst, Brønsted acid or Lewis acid promoter ...[more]